Colorful molecular diagnostics.
Clin Chem 58:4 (2012) 659-660
A protein biosensor that relies on bending of single DNA molecules.
Chemphyschem 13:4 (2012) 918-922
Abstract:
A "bendy" protein sensor: A DNA-based sensor that uses folded DNA (through DNA kinks) and protein-induced bending to detect DNA-binding proteins is presented. Single-molecule sensing of a transcriptional activator (catabolite activator protein, CAP, which bends its DNA site by 80°) is demonstrated in solution and on surfaces, both in buffers and in cell lysates. The method should allow detection of a wide range of DNA-bending proteins.Recognition of different DNA sequences by a DNA‐binding protein alters protein dynamics differentially
FEBS Letters Wiley 586:3 (2012) 258-262
Detection of Specific mRNA Synthesis in Rotavirus using Single Molecule Hybridization
BIOPHYSICAL JOURNAL 102:3 (2012) 287A-287A
In vivo single-molecule biochemistry of chromosome replication and segregation in bacteria.
MOLECULAR BIOLOGY OF THE CELL 23 (2012)