Theoretical astrophysics and plasma physics at RPC

Abstract:

BACKGROUND: Phenylalanine is converted to para- and ortho-tyrosine by hydroxyl free radical, or to para-tyrosine by the phenylalanine hydroxylase enzyme. The aim of this study was to measure para- and ortho-tyrosine in the urine and plasma of patients with chronic renal disease and/or diabetes, to obtain information on the renal handling of the different tyrosine isomers and, furthermore, to measure urinary levels of 8-epi-prostaglandin-F(2alpha), a marker of lipid peroxidation. METHODS: In our cross-sectional study we measured para-, ortho-tyrosine, and phenylalanine levels, using high performance liquid chromatography and 8-epi-prostaglandin-F(2alpha) with enzyme-linked immunosorbent assay (ELISA). We compared 4 groups: (1) controls (CONTR, N = 14), (2) patients with chronic kidney disease (CKD, N = 12), (3) patients with type 2 diabetes mellitus (DIAB, N = 17), (4) patients with chronic kidney disease and type 2 diabetes (DIAB-CKD, N = 19). RESULTS: We found a decreased plasma para-tyrosine level and decreased urinary para-tyrosine excretion in CKD patients, while the fractional excretion of para-tyrosine was similar in all 4 groups, approximately 1%. There was no difference in the plasma ortho-tyrosine levels between the groups. However, urinary ortho-tyrosine excretion was higher in all 3 groups of patients than in the CONTR group, and higher in DIAB and in DIAB-CKD patients than in CKD patients. The fractional excretion of ortho-tyrosine was significantly higher in DIAB and in DIAB-CKD patients than in the CONTR group. The fractional excretion of ortho-tyrosine exceeded 100% in the 2 diabetic groups. Urinary 8-epi-prostaglandin-F(2alpha)/creatinine ratio did not correlate with urinary ortho-tyrosine excretion. CONCLUSION: The difference between para-tyrosine levels of the groups is probably due to renal impairment, while there is indirect evidence for an increased tubular secretion or production of ortho-tyrosine in the kidney in diabetic patients with or without CKD.

Abstract:

We have obtained integral-field spectroscopy for 23 spiral bulges using INTEGRAL on the William Herschel Telescope and SPIRAL on the Anglo-Australian Telescope. This is the first two-dimensional survey directed solely at the bulges of spiral galaxies. Eleven galaxies of the sample do not have previous measurements of the stellar velocity dispersion (σ*). These data are designed to complement our Space Telescope Imaging Spectrograph program for estimating black hole masses in the range 10⁶-10⁸ M ⊙ using gas kinematics from nucleated disks. These observations will serve to derive the stellar dynamical bulge properties using the traditional Mg b and Ca II triplets. We use both cross-correlation and maximum penalized likelihood to determine projected σ* in these systems and present radial velocity fields, major axis rotation curves, curves of growth, and σ* fields. Using cross-correlation to extract the low-order two-dimensional stellar dynamics we generally see coherent radial rotation and irregular velocity dispersion fields suggesting that is a nontrivial parameter to estimate. © 2005, The American Astronomical Society. All rights reserved.