Professor Pedro Ferreira

Abstract:

A unified framework for theories of modified gravity will be an essential tool for interpreting the forthcoming deluge of cosmological data. We present such a formalism, the Parameterized Post-Friedmann framework (PPF), which parameterizes the cosmological perturbation theory of a wide variety of modified gravity models. PPF is able to handle spin-0 degrees of freedom from new scalar, vector and tensor fields, meaning that it is not restricted to simple models based solely on cosmological scalar fields. A direct correspondence is maintained between the parameterization and the underlying space of theories, which allows us to build up a `dictionary' of modified gravity theories and their PPF correspondences. In this paper we describe the construction of the parameterization and demonstrate its use through a number of worked examples relevant to the current literature. We indicate how the formalism will be implemented numerically, so that the dictionary of modified gravity can be pitted against forthcoming observations.

Abstract:

Euclid is a European Space Agency medium class mission selected for launch in 2019 within the Cosmic Vision 2015-2025 programme. The main goal of Euclid is to understand the origin of the accelerated expansion of the Universe. Euclid will explore the expansion history of the Universe and the evolution of cosmic structures by measuring shapes and redshifts of galaxies as well as the distribution of clusters of galaxies over a large fraction of the sky. Although the main driver for Euclid is the nature of dark energy, Euclid science covers a vast range of topics, from cosmology to galaxy evolution to planetary research. In this review we focus on cosmology and fundamental physics, with a strong emphasis on science beyond the current standard models. We discuss five broad topics: dark energy and modified gravity, dark matter, initial conditions, basic assumptions and questions of methodology in the data analysis. This review has been planned and carried out within Euclid's Theory Working Group and is meant to provide a guide to the scientific themes that will underlie the activity of the group during the preparation of the Euclid mission.

Abstract:

Alternative splicing is the mechanism by which different combinations of exons in the pre-mRNA give rise to distinct mature mRNAs. This process is mediated by splicing factors that bind the pre-mRNA and affect the recognition of its splicing signals. Saccharomyces species lack many of the regulatory factors present in metazoans. Accordingly, it is generally assumed that the amount of alternative splicing is limited. However, there is recent compelling evidence that yeast have functional alternative splicing, mainly in response to environmental conditions. We have previously shown that sequence and structure properties of the pre-mRNA could explain the selection of 3' splice sites (ss) in Saccharomyces cerevisiae. In this work, we extend our previous observations to build a computational classifier that explains most of the annotated 3'ss in the CDS and 5' UTR of this organism. Moreover, we show that the same rules can explain the selection of alternative 3'ss. Experimental validation of a number of predicted alternative 3'ss shows that their usage is low compared to annotated 3'ss. The majority of these alternative 3'ss introduce premature termination codons (PTCs), suggesting a role in expression regulation. Furthermore, a genome-wide analysis of the effect of temperature, followed by experimental validation, yields only a small number of changes, indicating that this type of regulation is not widespread. Our results are consistent with the presence of alternative 3'ss selection in yeast mediated by the pre-mRNA structure, which can be responsive to external cues, like temperature, and is possibly related to the control of gene expression.