Joseph Silk

Abstract:

We aim at reproducing the mass- and sigma-[alpha/Fe] relations in the stellar populations of early-type galaxies by means of a cosmologically motivated assembly history for the spheroids. We implement a detailed treatment for the chemical evolution of H, He, O and Fe in GalICS, a semi-analytical model for galaxy formation which successfully reproduces basic low- and high-redshift galaxy properties. The contribution of supernovae (both type Ia and II) as well as low- and intermediate-mass stars to chemical feedback are taken into account. We find that this chemically improved GalICS does not produce the observed mass- and sigma-[alpha/Fe] relations. The slope is too shallow and scatter too large, in particular in the low and intermediate mass range. The model shows significant improvement at the highest masses and velocity dispersions, where the predicted [alpha/Fe] ratios are now marginally consistent with observed values. We show that this result comes from the implementation of AGN (plus halo) quenching of the star formation in massive haloes. A thorough exploration of the parameter space shows that the failure of reproducing the mass- and sigma-[alpha/Fe] relations can partly be attributed to the way in which star formation and feedback are currently modelled. The merger process is responsible for a part of the scatter. We suggest that the next generation of semi-analytical model should feature feedback (either stellar of from AGN) mechanisms linked to single galaxies and not only to the halo, especially in the low and intermediate mass range. The integral star formation history of a single galaxy determines its final stellar [alpha/Fe] as it might be expected from the results of closed box chemical evolution models. (abridged)

Abstract:

Activation of invariant CD1d-dependent NK T cells (iNKT cells) in vivo through administration of the glycolipid ligand alpha-galactosylceramide (alpha-GalCer) or the sphingosine-truncated alpha-GalCer analog OCH leads to CD40 signaling as well as the release of soluble molecules including type 1 and gamma interferons that contribute to DC maturation. This process enhances T cell immunity to antigens presented by the DC. The adjuvant activity is further amplified if APCs are stimulated through Toll-like receptor 4, suggesting that iNKT cell signals can amplify maturation induced by microbial stimuli. The adjuvant activity of alpha-GalCer enhances both priming and boosting of CD8(+) T cells to coadministered peptide or protein antigens, including a peptide encoding the clinically relevant, HLA-A2-restricted epitope of the human tumor antigen NY-ESO-1. Importantly, alpha-GalCer was used to induce CD8(+) T cells to antigens delivered orally, despite the fact that this route of administration is normally associated with blunted responses. Only T cell responses induced in the presence of iNKT cell stimulation, whether by the i.v. or oral route, were capable of eradicating established tumors. Together these data highlight the therapeutic potential of iNKT cell ligands in vaccination strategies, particularly "heterologous prime-boost" strategies against tumors, and provide evidence that iNKT cell stimulation may be exploited in the development of oral vaccines.

Abstract:

The observed 511 keV emission from the galactic bulge could be due to very light (MeV) annihilating dark matter particles. To distinguish this hypothesis from conventional astrophysical sources, we study dwarf spheroidals in the region observed by the International Gamma-Ray Astrophysics Laboratory/SPI such as Sagittarius. As these galaxies have comparatively few stars, the prospects for 511 keV emission from standard astrophysical scenarios are minimal. The dwarf spheroidals do, however, contain copious amounts of dark matter. The observation of 511 keV emission from Sagittarius should be a "smoking gun" for MeV dark matter.