Joseph Silk

Abstract:

This contribution reports on our first efforts to simulate a multiphase interstellar medium on a kiloparsec scale in three dimensions with the stars and gas modeled self-consistently. Starting from inhomogenous initial conditions, our closed box simulations follow the gas as it cools and collapses under its own self-gravity to form stars which eventually return material and energy back through supernovae explosions and winds.

Abstract:

Modification in the function of dendritic cells (DC), such as that achieved by microbial stimuli or T cell help, plays a critical role in determining the quality and size of adaptive responses to Ag. NKT cells bearing an invariant TCR (iNKT cells) restricted by nonpolymorphic CD1d molecules may constitute a readily available source of help for DC. We therefore examined T cell responses to i.v. injection of soluble Ag in the presence or the absence of iNKT cell stimulation with the CD1d-binding glycolipid alpha-galactosylceramide (alpha-GalCer). Considerably enhanced CD4(+) and CD8(+) T cell responses were observed when alpha-GalCer was administered at the same time as or close to OVA injection. This enhancement was dependent on the involvement of iNKT cells and CD1d molecules and required CD40 signaling. Studies in IFN-gammaR(-/-) mice indicated that IFN-gamma was not required for the adjuvant effect of alpha-GalCer. Consistent with this result, enhanced T cell responses were observed using OCH, an analog of alpha-GalCer with a truncated sphingosine chain and a reduced capacity to induce IFN-gamma. Splenic DC from alpha-GalCer-treated animals expressed high levels of costimulatory molecules, suggesting maturation in response to iNKT cell activation. Furthermore, studies with cultured DC indicated that potentiation of T cell responses required presentation of specific peptide and alpha-GalCer by the same DC, implying conditioning of DC by iNKT cells. The iNKT-enhanced T cell responses resisted challenge with OVA-expressing tumors, whereas responses induced in the absence of iNKT stimulation did not. Thus, iNKT cells exert a significant influence on the efficacy of immune responses to soluble Ag by modulating DC function.

Abstract:

We present the first high-resolution N-body simulations of the fragmentation of dark matter filaments. Such fragmentation occurs in top-down scenarios of structure formation, when the dark matter is warm instead of cold. In a previous paper, we showed that warm dark matter (WDM) differs from the standard cold dark matter (CDM) mainly in the formation history and large-scale distribution of low-mass haloes, which form later and tend to be more clustered in WDM than in CDM universes, tracing the filamentary structures of the cosmic web more closely. Therefore, we focus our computational effort in this paper on one particular filament extracted from a WDM cosmological simulation and compare in detail its evolution to that of the same CDM filament. We find that the mass distribution of the haloes forming via fragmentation within the filament is broadly peaked around a Jeans mass of a few 109 M ⊙, corresponding to a gravitational instability of smooth regions with an overdensity contrast around 10 at these redshifts. Our results confirm that WDM filaments fragment and form gravitationally bound haloes in a top-down fashion, whereas CDM filaments are built bottom-up, thus demonstrating the impact of the nature of the dark matter on dwarf galaxy properties.