Malcolm John

Abstract:

This contribution reports on recent LHCb achievements in the pursuit of CKM triangle measurements and probes of CP violation in the charm system. These results are based on the 2010 dataset or, in some cases, preliminary results using the data collected by summer 2011. © Owned by the authors 2012.

Abstract:

HLA class I-associated polymorphisms identified at the population level mark viral sites under immune pressure by individual HLA alleles. As such, analysis of their distribution, frequency, location, statistical strength, sequence conservation, and other properties offers a unique perspective from which to identify correlates of protective cellular immunity. We analyzed HLA-associated HIV-1 subtype B polymorphisms in 1,888 treatment-naïve, chronically infected individuals using phylogenetically informed methods and identified characteristics of HLA-associated immune pressures that differentiate protective and nonprotective alleles. Over 2,100 HLA-associated HIV-1 polymorphisms were identified, approximately one-third of which occurred inside or within 3 residues of an optimally defined cytotoxic T-lymphocyte (CTL) epitope. Differential CTL escape patterns between closely related HLA alleles were common and increased with greater evolutionary distance between allele group members. Among 9-mer epitopes, mutations at HLA-specific anchor residues represented the most frequently detected escape type: these occurred nearly 2-fold more frequently than expected by chance and were computationally predicted to reduce peptide-HLA binding nearly 10-fold on average. Characteristics associated with protective HLA alleles (defined using hazard ratios for progression to AIDS from natural history cohorts) included the potential to mount broad immune selection pressures across all HIV-1 proteins except Nef, the tendency to drive multisite and/or anchor residue escape mutations within known CTL epitopes, and the ability to strongly select mutations in conserved regions within HIV's structural and functional proteins. Thus, the factors defining protective cellular immune responses may be more complex than simply targeting conserved viral regions. The results provide new information to guide vaccine design and immunogenicity studies.

Abstract:

Properties of the orbitally excited (L=1) $B_s$ states are studied using 1.0 fb$^{-1}$ of pp collisions at $\sqrt{s} =7$ TeV collected with the LHCb detector. The first observation of the $B_{s2}^*(5840)^0$ meson decaying to $B^{*+} K^-$ is reported, and the corresponding branching fraction measured relative to the $B^+ K^-$ decay mode. The $B_{s1}(5830)^0 \to B^{*+} K^-$ decay is observed as well. The width of the $B_{s2}^*(5840)^0$ state is measured for the first time and the masses of the two states are determined with the highest precision to date. The observation of the $B_{s2}^*(5840)^0 \to B^{*+} K^-$ decay favours the spin-parity assignment $J^P = 2^+$ for the $B_{s2}^*(5840)^0$ meson. In addition, the most precise measurement of the mass difference $m(B^{*+})-m(B^+) = 45.01 \pm 0.30 (stat) \pm 0.23 (syst)$ MeV/$c^2$ is obtained.

Abstract:

A search for the rare decays Bs->mu+mu- and B0->mu+mu- is performed using data collected in 2011 and 2012 with the LHCb experiment at the Large Hadron Collider. The data samples comprise 1.1 fb^-1 of proton-proton collisions at sqrt{s} = 8 TeV and 1.0 fb^-1 at sqrt{s}=7 TeV. We observe an excess of Bs -> mu+ mu- candidates with respect to the background expectation. The probability that the background could produce such an excess or larger is 5.3 x 10^-4 corresponding to a signal significance of 3.5 standard deviations. A maximum-likelihood fit gives a branching fraction of BR(Bs -> mu+ mu-) = (3.2^{+1.5}_{-1.2}) x 10^-9, where the statistical uncertainty is 95% of the total uncertainty. This result is in agreement with the Standard Model expectation. The observed number of B0 -> mu+ mu- candidates is consistent with the background expectation, giving an upper limit of BR(B0 -> mu+ mu-) < 9.4 x 10^-10 at 95% confidence level.