We work with synthetic biomolecular nanostructures built by self-assembly. Nucleic acid nanostructures are atomically precise and dynamically reconfigurable: by designing synthetic strands of DNA or RNA we can create autonomous molecular systems that sense, compute and actuate. We are developing the physics and technology of functional nucleic acid nanostructures to create disruptive technologies, including templates for molecular electronics and molecular machinery for atomically precise manufacture and chemical discovery. We are also working on probes of cellular structure and function.
Research interests
Biophysics
Self-assembly
Nanotechnology
Molecular Machinery
Selected publications
DNA origami signposts for identifying proteins on cell membranes by electron cryotomography
Cell Cell Press 184:4 (2021) 1110-1121.e16
Strategies for constructing and operating DNA origami linear actuators
Small Wiley 17:20 (2021) 2007704
Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
Nature Communications Springer Nature 11 (2020) 2562
Reconfigurable T‐junction DNA origami
Angewandte Chemie Wiley (2020) ange.202006281