Gene expression and DNA repair, one molecule at a time

We are a multi-disciplinary group working on understanding the mechanisms and machines of gene expression (the vital path that converts DNA information into functional proteins) and DNA repair. We are especially interested in these processes in microbial pathogens, such as bacteria and viruses. We observe the machines of interest in real time, both "in vitro" and inside living cells, and to do this, we use single-molecule biophysical methods and biochemistry as our main tools. We also develop single-molecule fluorescence methods, instruments, assays and DNA-based biosensors.

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