Ion microscope imaging mass spectrometry using a Timepix3-based optical camera

Journal of the American Society for Mass Spectrometry American Chemical Society 33:12 (2022) 2328-2332

Authors:

Daniel Wood, Robert J Burleigh, Natasha Smith, Daniela Bortoletto, Mark Brouard, Michael Burt, Andrei Nomerotski, Richard Plackett, Ian Shipsey

Abstract:

Ion microscopy allows for high-throughput mass spectrometry imaging. In order to resolve congested mass spectra, a high degree of timing precision is required from the microscope detector. In this paper we present an ion microscope mass spectrometer that uses a Timepix3 hybrid pixel readout with an optimal 1.56 ns resolution. A novel triggering technique is also employed to remove the need for an external time-to-digital converter (TDC) and allow the experiment to be performed using a low-cost and commercially available readout system. Results obtained from samples of rhodamine B demonstrate the application of multimass imaging sensors for microscope mass spectrometry imaging with high mass resolution.

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