The novel Mechanical Ventilator Milano for the COVID-19 pandemic

Physics of Fluids AIP Publishing 33:3 (2021) 037122

Authors:

A Abba, C Accorsi, P Agnes, Jeffrey Tseng

Abstract:

This paper presents the Mechanical Ventilator Milano (MVM), a novel intensive therapy mechanical ventilator designed for rapid, large-scale, low-cost production for the COVID-19 pandemic. Free of moving mechanical parts and requiring only a source of compressed oxygen and medical air to operate, the MVM is designed to support the long-term invasive ventilation often required for COVID-19 patients and operates in pressure-regulated ventilation modes, which minimize the risk of furthering lung trauma. The MVM was extensively tested against ISO standards in the laboratory using a breathing simulator, with good agreement between input and measured breathing parameters and performing correctly in response to fault conditions and stability tests. The MVM has obtained Emergency Use Authorization by U.S. Food and Drug Administration (FDA) for use in healthcare settings during the COVID-19 pandemic and Health Canada Medical Device Authorization for Importation or Sale, under Interim Order for Use in Relation to COVID-19. Following these certifications, mass production is ongoing and distribution is under way in several countries. The MVM was designed, tested, prepared for certification, and mass produced in the space of a few months by a unique collaboration of respiratory healthcare professionals and experimental physicists, working with industrial partners, and is an excellent ventilator candidate for this pandemic anywhere in the world.

Cosmic shear power spectra in practice

Journal of Cosmology and Astroparticle Physics IOP Publishing 2021:3 (2021) 067

Authors:

A Nicola, Carlos Garcia-Garcia, David Alonso, J Dunkley, Pedro Ferreira, A Slosar, Dn Spergel

Abstract:

Cosmic shear is one of the most powerful probes of Dark Energy, targeted by several current and future galaxy surveys. Lensing shear, however, is only sampled at the positions of galaxies with measured shapes in the catalog, making its associated sky window function one of the most complicated amongst all projected cosmological probes of inhomogeneities, as well as giving rise to inhomogeneous noise. Partly for this reason, cosmic shear analyses have been mostly carried out in real-space, making use of correlation functions, as opposed to Fourier-space power spectra. Since the use of power spectra can yield complementary information and has numerical advantages over real-space pipelines, it is important to develop a complete formalism describing the standard unbiased power spectrum estimators as well as their associated uncertainties. Building on previous work, this paper contains a study of the main complications associated with estimating and interpreting shear power spectra, and presents fast and accurate methods to estimate two key quantities needed for their practical usage: the noise bias and the Gaussian covariance matrix, fully accounting for survey geometry, with some of these results also applicable to other cosmological probes. We demonstrate the performance of these methods by applying them to the latest public data releases of the Hyper Suprime-Cam and the Dark Energy Survey collaborations, quantifying the presence of systematics in our measurements and the validity of the covariance matrix estimate. We make the resulting power spectra, covariance matrices, null tests and all associated data necessary for a full cosmological analysis publicly available.

The black hole transient MAXI J1348-630: evolution of the compact and transient jets during its 2019/2020 outburst

(2021)

Authors:

F Carotenuto, S Corbel, E Tremou, TD Russell, A Tzioumis, RP Fender, PA Woudt, SE Motta, JCA Miller-Jones, J Chauhan, AJ Tetarenko, GR Sivakoff, I Heywood, A Horesh, AJ van der Horst, E Koerding, KP Mooley

Theoretical priors in scalar-tensor cosmologies: Shift-symmetric Horndeski models

(2021)

Authors:

Dina Traykova, Emilio Bellini, Pedro G Ferreira, Carlos García-García, Johannes Noller, Miguel Zumalacárregui

Disk, corona, jet connection in the intermediate state of MAXI J1820+070 revealed by NICER spectral-timing analysis

Astrophysical Journal Letters IOP Science 910:1 (2021) L3

Authors:

Jingyi Wang, Guglielmo Mastroserio, Erin Kara, Javier A Garcia, Adam Ingram, Riley Connors, Michiel van der Klis, Thomas Dauser, James F Steiner, Douglas JK Buisson, Jeroen Homan, Matteo Lucchini, Andrew C Fabian, Joe Bright, Rob Fender, Edward M Cackett, Ron A Remillard

Abstract:

We analyze five epochs of Neutron star Interior Composition Explorer (NICER) data of the black hole X-ray binary MAXI J1820+070 during the bright hard-to-soft state transition in its 2018 outburst with both reflection spectroscopy and Fourier-resolved timing analysis. We confirm the previous discovery of reverberation lags in the hard state, and find that the frequency range where the (soft) reverberation lag dominates decreases with the reverberation lag amplitude increasing during the transition, suggesting an increasing X-ray emitting region, possibly due to an expanding corona. By jointly fitting the lag-energy spectra in a number of broad frequency ranges with the reverberation model reltrans, we find the increase in reverberation lag is best described by an increase in the X-ray coronal height. This result, along with the finding that the corona contracts in the hard state, suggests a close relationship between spatial extent of the X-ray corona and the radio jet. We find the corona expansion (as probed by reverberation) precedes a radio flare by ∼5 days, which may suggest that the hard-to-soft transition is marked by the corona expanding vertically and launching a jet knot that propagates along the jet stream at relativistic velocities.