The novel Mechanical Ventilator Milano for the COVID-19 pandemic
Physics of Fluids AIP Publishing 33:3 (2021) 037122
Abstract:
This paper presents the Mechanical Ventilator Milano (MVM), a novel intensive therapy mechanical ventilator designed for rapid, large-scale, low-cost production for the COVID-19 pandemic. Free of moving mechanical parts and requiring only a source of compressed oxygen and medical air to operate, the MVM is designed to support the long-term invasive ventilation often required for COVID-19 patients and operates in pressure-regulated ventilation modes, which minimize the risk of furthering lung trauma. The MVM was extensively tested against ISO standards in the laboratory using a breathing simulator, with good agreement between input and measured breathing parameters and performing correctly in response to fault conditions and stability tests. The MVM has obtained Emergency Use Authorization by U.S. Food and Drug Administration (FDA) for use in healthcare settings during the COVID-19 pandemic and Health Canada Medical Device Authorization for Importation or Sale, under Interim Order for Use in Relation to COVID-19. Following these certifications, mass production is ongoing and distribution is under way in several countries. The MVM was designed, tested, prepared for certification, and mass produced in the space of a few months by a unique collaboration of respiratory healthcare professionals and experimental physicists, working with industrial partners, and is an excellent ventilator candidate for this pandemic anywhere in the world.The black hole transient MAXI J1348-630: evolution of the compact and transient jets during its 2019/2020 outburst
(2021)
Theoretical priors in scalar-tensor cosmologies: Shift-symmetric Horndeski models
(2021)
Disk, corona, jet connection in the intermediate state of MAXI J1820+070 revealed by NICER spectral-timing analysis
Astrophysical Journal Letters IOP Science 910:1 (2021) L3
Abstract:
We analyze five epochs of Neutron star Interior Composition Explorer (NICER) data of the black hole X-ray binary MAXI J1820+070 during the bright hard-to-soft state transition in its 2018 outburst with both reflection spectroscopy and Fourier-resolved timing analysis. We confirm the previous discovery of reverberation lags in the hard state, and find that the frequency range where the (soft) reverberation lag dominates decreases with the reverberation lag amplitude increasing during the transition, suggesting an increasing X-ray emitting region, possibly due to an expanding corona. By jointly fitting the lag-energy spectra in a number of broad frequency ranges with the reverberation model reltrans, we find the increase in reverberation lag is best described by an increase in the X-ray coronal height. This result, along with the finding that the corona contracts in the hard state, suggests a close relationship between spatial extent of the X-ray corona and the radio jet. We find the corona expansion (as probed by reverberation) precedes a radio flare by ∼5 days, which may suggest that the hard-to-soft transition is marked by the corona expanding vertically and launching a jet knot that propagates along the jet stream at relativistic velocities.The infrared-radio correlation of star-forming galaxies is strongly M-star-dependent but nearly redshift-invariant since z similar to 4
Astronomy and Astrophysics European Southern Observatory 647 (2021) A123