Beecroft Institute for Particle Astrophysics and Cosmology

Abstract:

Under ideal MHD conditions the magnetic field strength should be correlated with density in the interstellar medium (ISM). However, observations indicate that this correlation is weak. Ambipolar diffusion can decrease the flux-to-mass ratio in weakly ionized media; however, it is generally thought to be too slow to play a significant role in the ISM except in the densest molecular clouds. Turbulence is often invoked in astrophysical problems to increase transport rates above the (very slow) laminar values predicted by kinetic theory. We describe a series of numerical experiments addressing the problem of turbulent transport of magnetic fields in weakly ionized gases. We show, subject to various geometrical and physical restrictions, that turbulence in a weakly ionized medium rapidly diffuses the magnetic flux to mass ratio through the buildup of appreciable ion-neutral drifts on small scales. These results are applicable to the fieldstrength - density correlation in the ISM, as well as the merging of flux systems such as protostar and accretion disk fields or protostellar jets with ambient matter, and the vertical transport of galactic magnetic fields.

Abstract:

Under ideal MHD conditions the magnetic field strength should be correlated with density in the interstellar medium (ISM). However, observations indicate that this correlation is weak. Ambipolar diffusion can decrease the flux-to-mass ratio in weakly ionized media; however, it is generally thought to be too slow to play a significant role in the ISM except in the densest molecular clouds. Turbulence is often invoked in astrophysical problems to increase transport rates above the (very slow) laminar values predicted by kinetic theory. We describe a series of numerical experiments addressing the problem of turbulent transport of magnetic fields in weakly ionized gases. We show, subject to various geometrical and physical restrictions, that turbulence in a weakly ionized medium rapidly diffuses the magnetic flux-to-mass ratio B/ρ through the buildup of appreciable ion-neutral drifts on small scales. These results are applicable to the field strength-density correlation in the ISM, as well as the merging of flux systems such as protostar and accretion disk fields or protostellar jets with ambient matter, and the vertical transport of galactic magnetic fields.

Abstract:

Assessment of cell-mediated toxicity has traditionally been achieved by measuring the specific activity of enriched effector cell populations against antigen-loaded target cells labeled with radioactive isotopes in vitro. Fluorometric techniques are viewed as a promising alternative to the use of radioactive isotopes for these analyses. Direct assessment of cytotoxicity in vivo can be achieved by monitoring survival of injected fluorescent targets relative to a differentially labeled internal control population without specific antigen. We have developed this approach, incorporating the use of multiple target cell populations labeled with different dyes so that cytotoxicity can be assessed against titrated doses of a given antigen, or against a range of different antigens, simultaneously. We show that this assay, referred to as the VITAL assay, can be used to assess cytotoxic activity of CTL and iNKT cells in vivo and in vitro. CTL responses measured in vivo could be correlated with antigen doses used in immunization strategies, and also with the size of specific CTL populations enumerated in the blood with fluorescent MHC/peptide tetramers. The VITAL assay is, therefore, a sensitive technique allowing analysis of complex multi-epitope responses.