Counting Connected and Disconnected Ways to Assemble a Jigsaw Puzzle

(2026)

Authors:

Prarthana Agrawal, Abdurrahman Hadi Erturk, Ard A Louis

Multi-phase field model reveals internal dissipation is crucial for spontaneous hole formation in cell monolayers

Nature Communications Springer Nature (2026)

Authors:

Diogo EP Pinto, Jan Rozman, Julia M Yeomans

Abstract:

Although cell monolayers typically remain confluent, they can spontaneously develop persistent holes as a result of collective cellular motion. Recent studies on MDCK monolayers cultured on soft substrates have revealed that cells can align to create regions of local nematic order, and topological defects that generate localised mechanical stresses which can spontaneously trigger hole formation. To investigate this process, we develop a continuum multi-phase field model that incorporates internal dissipation and active dipolar forces that drive cell shape anisotropy. Our simulations show that reducing substrate friction enhances cell-cell velocity correlations. In the low-friction regime, topological defects generate spiral flow patterns that concentrate stress and can trigger hole formation. By contrast, in the high-friction regime, holes do not nucleate. We further demonstrate that the number and stability of the holes—whether they close or persist—depends on both substrate friction and cellular activity, through a non-dimensional friction number. These findings highlight the importance of internal dissipation in modelling collective cell motion and the critical role of collective dynamics in maintaining tissue integrity.

Chaotic Many-Body Quantum Dynamics, Spectral Correlations, and Energy Diffusion

Physical Review X American Physical Society (APS) 16:3 (2026) 031076

Authors:

JT Chalker, Dominik Hahn

Abstract:

We study chaotic many-body quantum dynamics in a minimal model with spatial structure and local interactions. It has a time-independent Hamiltonian, in contrast to quantum circuits and Brownian models, and is simple at the single-site level, in contrast to Sachdev-Ye-Kitaev chains. It is analytically tractable for large local Hilbert space dimension and weak intersite coupling. In this limit, we show that energy dynamics is described by a classical master equation and is diffusive. We also show that the spectral form factor can be expressed exactly in terms of the solution to this master equation. For a two-site system, we obtain closed-form expressions for both the two-point correlator of energy density and the spectral form factor, in essentially perfect agreement with numerical simulations. For an L -site system we show at late times how a linear ramp emerges in the spectral form factor, as universally expected from level repulsion in chaotic quantum systems. Conversely, at earlier times we identify two distinct mechanisms for an increase of the spectral form factor above its ramp value. One of these is associated with energy diffusion and is effective until the Thouless time, which varies as L 2 . The other involves contributions like those that would appear if the system were composed of many uncoupled subsystems: They generate a large enhancement of the spectral form factor and are suppressed on a timescale varying as ( ln L ) 2 . Besides being exact for the limit considered, we believe our approach provides the natural approximation even for small local Hilbert space dimension and strong intersite coupling. We present a numerical study of a spin-half chain, finding an early-time enhancement of the spectral form factor which is qualitatively similar to that in our solvable model.

Efficient quantum thermal state preparation via local driving: Lindbladian simulation with provable guarantees

Physical Review B American Physical Society (APS) 114:1 (2026) 14302

Authors:

Dominik Hahn, Sa Parameswaran, Benedikt Placke

Abstract:

<jats:p> Preparing the thermal density matrix <a:math xmlns:a="http://www.w3.org/1998/Math/MathML"> <a:mrow> <a:msub> <a:mi>ρ</a:mi> <a:mi>β</a:mi> </a:msub> <a:mo>∝</a:mo> <a:msup> <a:mi>e</a:mi> <a:mrow> <a:mo>−</a:mo> <a:mi>β</a:mi> <a:mi>H</a:mi> </a:mrow> </a:msup> </a:mrow> </a:math> corresponding to a given Hamiltonian <b:math xmlns:b="http://www.w3.org/1998/Math/MathML"> <b:mi>H</b:mi> </b:math> is a task of central interest across quantum many-body physics, and is particularly salient when attempting to study it with quantum computers. Although solved in principle by recent constructions of efficiently simulable Lindblad master equations—that provably have <c:math xmlns:c="http://www.w3.org/1998/Math/MathML"> <c:msub> <c:mi>ρ</c:mi> <c:mi>β</c:mi> </c:msub> </c:math> as a steady state [C.-F. Chen , ]—the implementation of these “exact Gibbs samplers” requires large-scale quantum computing resources and is hence challenging in practice on current or even near-term quantum devices. Here, we propose a scheme for approximately simulating an exact Gibbs sampler up to a rigorously bounded error that only requires the (repeated) implementation of three readily available ingredients: (a) analog simulation of <d:math xmlns:d="http://www.w3.org/1998/Math/MathML"> <d:mi>H</d:mi> </d:math> ; (b) strictly local but time-dependent couplings to ancilla qubits; and (c) reset of the ancillas. We give rigorous guarantees on the difference between the fixed point reached by our protocol and the exact thermal state, which only depend on parameters of the protocol and its . The procedure is efficiently implementable on near-term devices if <e:math xmlns:e="http://www.w3.org/1998/Math/MathML"> <e:mi>H</e:mi> </e:math> is local and the mixing time scales mildly with both system size and protocol parameters. While guaranteeing the latter for Hamiltonians of interest remains an important problem for future work, here we lay the groundwork for developing fully efficient thermal state preparation protocols on quantum simulators. </jats:p>

Intermittent motility of a synthetic active particle in changing environments

Physical Review E American Physical Society (APS) 114:1 (2026) l013103

Authors:

Rudra Sekhri, Rahil N Valani, Tapio Simula

Abstract:

We experimentally investigate the dynamics of synthetic active particles composed of gravitationally bouncing, superwalking droplets confined within an annular fluid bath. Driven by a topologically pumping dual-frequency waveform, the droplets exhibit alternating active (walking) and dormant (bouncing) phases, producing intermittent azimuthal motion. Tracking individual droplets reveals pseudolaminar chaotic dynamics in the time series of the particle's angular position, characterized by laminar plateaus that are interrupted by short, irregular bursts of activity. Increasing the driving amplitude induces a qualitative change in the active particle's intermittent dynamics, arising from a symmetry-breaking transition in its Faraday-wave field environment: continuous SO(2)-symmetric “channeling” waves give way to discrete “trapping” patterns. These findings demonstrate how environmental symmetry and spatiotemporal structure modulate motility and intermittency in synthetic active matter.