Ion channels

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A unique lower X-gate in TASK channels traps inhibitors within the vestibule

Authors:

Karin EJ Rödström, Aytuğ K Kiper, Wei Zhang, Susanne Rinné, Ashley CW Pike, Matthias Goldstein, Linus Conrad, Martina Delbeck, Michael Hahn, Heinrich Meier, Magdalena Platzk, Andrew Quigley, David Speedman, Leela Shrestha, Shubhashish MM Mukhopadhyay, Nicola A Burgess-Brown, Stephen J Tucker, Thomas Mueller, Niels Decher, Elisabeth P Carpenter
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CryoEM Structure of the human THIK-1 K2P K+ Channel Reveals a Lower ‘Y-gate’ Regulated by Lipids and Anaesthetics

Authors:

Karin EJ Rödström, Bisher Eymsh, Peter Proks, Mehtab S Hayre, Christian Madry, Anna Rowland, Simon Newstead, Thomas Baukrowitz, Marcus Schewe, Stephen J Tucker
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Defective X-gating caused by de novo gain-of-function mutations in KCNK3 underlies a developmental disorder with sleep apnea

Authors:

Janina Sörmann, Marcus Schewe, Peter Proks, Thibault Jouen-Tachoire, Shanlin Rao, Elena B Riel, Katherine E Agre, Amber Begtrup, John Dean, Maria Descartes, Jan Fischer, Alice Gardham, Carrie Lahner, Paul R Mark, Srikanth Muppidi, Pavel N Pichurin, Joseph Porrmann, Jens Schallner, Kirstin Smith, Volker Straub, Pradeep Vasudevan, Rebecca Willaert, Elisabeth P Carpenter, Karin EJ Rödström, Michael G Hahn, Thomas Müller, Thomas Baukrowitz, Matthew E Hurles, Caroline F Wright, Stephen J Tucker
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Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation

Authors:

Karin EJ Rödström, Alexander Cloake, Janina Sörmann, Agnese Baronina, Kathryn HM Smith, Ashley CW Pike, Jackie Ang, Peter Proks, Marcus Schewe, Ingelise Holland-Kaye, Simon R Bushell, Jenna Elliott, Els Pardon, Thomas Baukrowitz, Raymond J Owens, Simon Newstead, Jan Steyaert, Elisabeth P Carpenter, Stephen J Tucker
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Induced Polarization in MD Simulations of the 5HT3 Receptor Channel

Cold Spring Harbor Laboratory 2020.03.01.971853

Authors:

Gianni Klesse, Shanlin Rao, Stephen J Tucker, Mark SP Sansom
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