Beecroft Institute for Particle Astrophysics and Cosmology

Abstract:

We consider the Gumbel or extreme value statistics describing the distribution function p_G(x_max) of the maximum values of a random field x within patches of fixed size. We present, for smooth Gaussian random fields in two and three dimensions, an analytical estimate of p_G which is expected to hold in a regime where local maxima of the field are moderately high and weakly clustered. When the patch size becomes sufficiently large, the negative of the logarithm of the cumulative extreme value distribution is simply equal to the average of the Euler Characteristic of the field in the excursion x > x_max inside the patches. The Gumbel statistics therefore represents an interesting alternative probe of the genus as a test of non Gaussianity, e.g. in cosmic microwave background temperature maps or in three-dimensional galaxy catalogs. It can be approximated, except in the remote positive tail, by a negative Weibull type form, converging slowly to the expected Gumbel type form for infinitely large patch size. Convergence is facilitated when large scale correlations are weaker. We compare the analytic predictions to numerical experiments for the case of a scale-free Gaussian field in two dimensions, achieving impressive agreement between approximate theory and measurements. We also discuss the generalization of our formalism to non-Gaussian fields.

Abstract:

Two of the dominant channels for galaxy mass assembly are cold flows (cold gas supplied via the filaments of the cosmic web) and mergers. How these processes combine in a cosmological setting, at both low and high redshift, to produce the whole zoo of galaxies we observe is largely unknown. Indeed there is still much to understand about the detailed physics of each process in isolation. While these formation channels have been studied using hydrodynamical simulations, here we study their impact on gas properties and star formation (SF) with some of the first simulations that capture the multiphase, cloudy nature of the interstellar medium (ISM), by virtue of their high spatial resolution (and corresponding low temperature threshold). In this regime, we examine the competition between cold flows and a supernovae(SNe)-driven outflow in a very high-redshift galaxy (z {\approx} 9) and study the evolution of equal-mass galaxy mergers at low and high redshift, focusing on the induced SF. We find that SNe-driven outflows cannot reduce the cold accretion at z {\approx} 9 and that SF is actually enhanced due to the ensuing metal enrichment. We demonstrate how several recent observational results on galaxy populations (e.g. enhanced HCN/CO ratios in ULIRGs, a separate Kennicutt Schmidt (KS) sequence for starbursts and the population of compact early type galaxies (ETGs) at high redshift) can be explained with mechanisms captured in galaxy merger simulations, provided that the multiphase nature of the ISM is resolved.

Abstract:

Murine cytomegalovirus (MCMV) is an important animal model of human cytomegalovirus (HCMV), a β-Herpesvirus that infects the majority of the world's population and causes disease in neonates and immunocompromised adults. CD8(+) T cells are a major part of the immune response to MCMV and HCMV. Processing of peptides for presentation to CD8(+) T cells may be critically dependent on the immunoproteasome, expression of which is affected by MCMV. However, the overall importance of the immunoproteasome in the generation of immunodominant peptides from MCMV is not known. We therefore examined the role of the immunoproteasome in stimulation of CD8(+) T cell responses to MCMV - both conventional memory responses and those undergoing long-term expansion or "inflation". We infected LMP7(-/-) and C57BL/6 mice with MCMV or with newly-generated recombinant vaccinia viruses (rVVs) encoding the immunodominant MCMV protein M45 in either full-length or epitope-only minigene form. We analysed CD8(+) T cell responses using intracellular cytokine stain (ICS) and MHC Class I tetramer staining for a panel of MCMV-derived epitopes. We showed a critical role for immunoproteasome in MCMV affecting all epitopes studied. Interestingly we found that memory "inflating" epitopes demonstrate reduced immunoproteasome dependence compared to non-inflating epitopes. M45-specific responses induced by rVVs remain immunoproteasome-dependent. These results help to define a critical restriction point for CD8(+) T cell epitopes in natural cytomegalovirus (CMV) infection and potentially in vaccine strategies against this and other viruses.