Ion channels

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Functional Analysis of Mutations in the TRESK K2P Potassium Channel Associated with ‘migraine with Aura’

Biophysical Journal Elsevier 100:3 (2011) 279a

Authors:

Isabelle Andres-Enguix, Lijun Shang, Phillip Stansfeld, Mark SP Sansom, M Zameel Cader, Stephen J Tucker
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Identification of Gating Mutations in the Trek-1 k2p Potassium Channel by Functional Complementation in K+ uptake Deficient Yeast

Biophysical Journal Elsevier 100:3 (2011) 279a-280a

Authors:

Chetan Sharma, Murali K Bollepalli, Thomas Baukrowitz, Stephen J Tucker
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PIP2-Binding to an Open State Model of Kir1.1 Probed by Multiscale Biomolecular Simulations

Biophysical Journal Elsevier 100:3 (2011) 431a

Authors:

Matthias R Schmidt, Phillip J Stansfeld, Markus Rapedius, Thomas Baukrowitz, Stephen J Tucker, Mark SP Sansom
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The Kir5.1 Potassium Channel is an Important Determinant of Neuronal PCO2/pH Sensitivity

Biophysical Journal Elsevier 100:3 (2011) 430a

Authors:

M Cristina D'Adamo, Lijun Shang, Paola Imbrici, Steve DM Brown, Mauro Pessia, Stephen J Tucker
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Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity.

The Journal of biological chemistry 286:1 (2011) 192-198

Authors:

M Cristina D'Adamo, Lijun Shang, Paola Imbrici, Steve DM Brown, Mauro Pessia, Stephen J Tucker

Abstract:

The molecular identity of ion channels which confer PCO(2)/pH sensitivity in the brain is unclear. Heteromeric Kir4.1/Kir5.1 channels are highly sensitive to inhibition by intracellular pH and are widely expressed in several brainstem nuclei involved in cardiorespiratory control, including the locus coeruleus. This has therefore led to a proposed role for these channels in neuronal CO(2) chemosensitivity. To examine this, we generated mutant mice lacking the Kir5.1 (Kcnj16) gene. We show that although locus coeruleus neurons from Kcnj16((+/+)) mice rapidly respond to cytoplasmic alkalinization and acidification, those from Kcnj16((-/-)) mice display a dramatically reduced and delayed response. These results identify Kir5.1 as an important determinant of PCO(2)/pH sensitivity in locus coeruleus neurons and suggest that Kir5.1 may be involved in the response to hypercapnic acidosis.
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