Oxford Molecular Motors

Abstract:

The cosmological principle asserts that on sufficiently large scales the Universe is homogeneous and isotropic on spatial slices. To deviate from this principle requires a departure from the FLRW ansatz. In this paper we analyze the cosmological evolution of two spatially homogeneous but anisotropic universes, namely the spatially closed Kantowski–Sachs Universe and the open axisymmetric Bianchi type III Universe. These models are characterized by two scale factors and we study their evolution in universes with radiation, matter and a cosmological constant. In all cases, the two scale factors evolve differently and this anisotropy leads to a lensing effect in the propagation of light. We derive explicit formulae for computing redshifts, angular diameter distances and luminosity distances and discuss the predictions of these models in relation to observations for type Ia supernovae and the CMB. We comment on the possibility of explaining the observed luminosity distance plot for type Ia supernovae within the context of cosmologies featuring late-time anisotropy and a vanishing cosmological constant.

Abstract:

Cells must access resources to survive, and the anatomy of multicellular structures influences this access. In diverse multicellular eukaryotes, resources are provided by internal conduits that allow substances to travel more readily through tissue than they would via diffusion. Microbes growing in multicellular structures, called biofilms, are also affected by differential access to resources and we hypothesized that this is influenced by the physical arrangement of the cells. In this study, we examined the microanatomy of biofilms formed by the pathogenic bacterium Pseudomonas aeruginosa and discovered that clonal cells form striations that are packed lengthwise across most of a mature biofilm's depth. We identified mutants, including those defective in pilus function and in O-antigen attachment, that show alterations to this lengthwise packing phenotype. Consistent with the notion that cellular arrangement affects access to resources within the biofilm, we found that while the wild type shows even distribution of tested substrates across depth, the mutants show accumulation of substrates at the biofilm boundaries. Furthermore, we found that altered cellular arrangement within biofilms affects the localization of metabolic activity, the survival of resident cells, and the susceptibility of subpopulations to antibiotic treatment. Our observations provide insight into cellular features that determine biofilm microanatomy, with consequences for physiological differentiation and drug sensitivity.