Unravelling the reaction mechanism and kinetics of dnazymes based on bulk and single molecule studies
MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (2020) 1109-1110
Abstract:
In this work we present a mathematical approach to model the kinetic behavior of DNA enzymes (DNAzymes) in order to predict their activity, which will assist future sequence designs. The model has been designed based on multiple previous reports since no general reaction mechanism has been fully described for DNAzymes to date. To better understand this, we also present first of its kind study of the DNAzyme catalytic reaction at the single molecule (SM) level.Single-Molecule FRET Assay for Studying Cotranscriptional RNA Folding
Methods in Molecular Biology Springer Nature 2106 (2020) 271-282
Rapid functionalisation and detection of viruses via a novel Ca2+-mediated virus-DNA interaction
Scientific Reports Nature Research 9 (2019) 16219
Confinement-free wide-field ratiometric tracking of single fluorescent molecules
Biophysical Journal Elsevier 117:11 (2019) 2141-2153
High-Throughput Detection and Manipulation of Single Nitrogen-Vacancy Center's Charge in Nanodiamonds
(2019)