Oxford Centre for High Energy Density Science (OxCHEDS)

Abstract:

A hydrogen plasma waveguide for high-intensity laser pulses is described. The guiding channel is formed by a small-scale discharge in a hydrogen-filled capillary. The measured lifetime of the capillary is inferred to be greater than 106 shots. The results of interferometric measurements of the electron density in the capillary are presented. The guiding channel is found to be highly ionized with an axial electron density of 2.7 ×1018 cm-3, and parabolic, the curvature corresponding to a matched spot-size of 37.5 μm. ©2000 The American Physical Society.

Abstract:

We present measurements of the electron density profile in the guiding channel of a novel plasma waveguide. The results of experiments to demonstrate guiding at peak intensities of >10−17 W cm−2 will be presented.

Abstract:

Nuclear activation has been observed in materials exposed to the ablated plasma generated from high intensity laser-solid interactions (at focused intensities up to 2 × 1019 W/cm2) and is produced by protons having energies up to 30 MeV. The energy spectrum of the protons is determined from these activation measurements and is found to be consistent with other ion diagnostics. The possible development of this technique for "table-top" production of radionuclides for medical applications is also discussed.

Abstract:

Time-resolved x-ray diffraction experiments are presented showing ultrafast modulation of anomalous transmission and recurrence of Pendellosung oscillations in thick crystals. These results are discussed in the context of coherent control and femtosecond x-ray pulse generation.

Abstract:

Objective

Classical growth hormone insensitivity syndrome (GHIS) comprises a dysmorphic phenotype, extreme short stature (height SDS < 3), normal GH and low IGF-I and IGFBP-3. Wide clinical variation is recognised with classical and atypical forms. We aimed to delineate features of the milder "atypical" GHIS phenotype, and to determine whether this correlates with milder auxological and biochemical features.

Methods

Fifty-nine patients from a European series of 82 patients with GHIS, with strict diagnostic criteria of GHIS, were studied and assigned to classical or atypical GHIS groups according to facial phenotype, i.e. "classical" required 2 of 3 recognized GHIS features (frontal bossing, mid-facial hypoplasia and depressed nasal bridge), "atypical" required 0 or 1 of these facial features. Classical and atypical GHIS groups were compared in terms of (1) phenotypic features, including high-pitched voice, sparse hair, blue sclera, hypoglycaemia, microphallus, (2) birth length, height SDS, and (3) basal IGF-I, IGF-II, IGFBP-1, IGFBP-3, GHBP and increase in IGF-I on IGF-I generation testing.

Results

Fifty patients [24 males, 26 females, aged 8.6 +/- 4.6 years (mean +/- SD)] had "classical GHIS", 9 patients (7 males, 2 females, aged 7.8 +/- 4.1 years) had "atypical GHIS", 7 with normal facies. Atypical GHIS patients had lesser height deficit (Ht SDS -4.0 +/- 1.4) compared to classical GHIS (-6.7 +/- 1.4), less reduction in IGFBP-3 SDS (atypical -5.5 +/- 3.3; classical -8.6 +/- 2.4), and more had normal GHBP (>10% binding). Other variables were also less frequent in atypical GHIS patients: high-pitched voice 11% (70% classical), sparse hair 11% (42% classical), blue sclera 0% (38% classical), hypoglycaemia 11% (42% classical), and microphallus 14% (1 of 7 males), compared to 79% of classical (19 of 24 males).

Conclusions

Atypical GHIS patients, with relatively normal facial appearance, demonstrate less height defect and biochemical abnormalities compared to classical patients. GH insensitivity may be present in children with short stature and an otherwise normal appearance.