Prof Ramin Golestanian

Abstract:

The structure of DNA in the nucleosome core particle is studied using an elastic model that incorporates anisotropy in the bending energetics and twist-bend coupling. Using the experimentally determined structure of nucleosomal DNA [T. J. Richmond and C. A. Davey, Nature (London) 423, 145 (2003)], it is shown that elastic correlations exist between twist, roll, tilt, and stretching of DNA, as well as the distance between phosphate groups. The twist-bend coupling term is shown to be able to capture these correlations to a large extent, and a fit to the experimental data yields a new estimate of G = 25 nm for the value of the twist-bend coupling constant.

Abstract:

A simple model for the reaction-driven propulsion of a small device is proposed as a model for (part of) a molecular machine in aqueous media. The motion of the device is driven by an asymmetric distribution of reaction products. The propulsive velocity of the device is calculated as well as the scale of the velocity fluctuations. The effects of hydrodynamic flow as well as a number of different scenarios for the kinetics of the reaction are addressed.

Abstract:

Multivalent ions can induce condensation of like-charged polyelectrolytes into compact states, a process that requires different ion valence for different polyelectrolyte species. We have examined the trivalent ion-induced condensation behavior in binary anionic polyelectrolyte mixtures consisting of DNA coils and F-actin rods, and observe a micro-phase separation between the two polyelectrolytes into coexisting finite-sized F-actin bundles and DNA toroids. Further, by increasing the DNA volume fraction in the mixture, condensed F-actin bundles can be completely destabilized, leading to only DNA condensation within the mixture. We examine a number of possible causes and propose a model based on polyelectrolyte competition for ions. © EDP Sciences.

Abstract:

We study the propulsion of two model swimmers at low Reynolds number. Inspired by Purcell's model, we propose a very simple one-dimensional swimmer consisting of three spheres that are connected by two arms whose lengths can change between two values. The proposed swimmer can swim with a special type of motion, which breaks the time-reversal symmetry. We also show that an ellipsoidal membrane with tangential travelling wave on it can also propel itself in the direction preferred by the travelling wave. This system resembles the realistic biological animals like Paramecium. © 2005 IOP Publishing Ltd.