Fluid flows on many scales
NATURE PHYSICS 17:6 (2021) 756-756
Activity pulses induce spontaneous flow reversals in viscoelastic environments.
Journal of the Royal Society, Interface 18:177 (2021) 20210100
Abstract:Complex interactions between cellular systems and their surrounding extracellular matrices are emerging as important mechanical regulators of cell functions, such as proliferation, motility and cell death, and such cellular systems are often characterized by pulsating actomyosin activities. Here, using an active gel model, we numerically explore spontaneous flow generation by activity pulses in the presence of a viscoelastic medium. The results show that cross-talk between the activity-induced deformations of the viscoelastic surroundings and the time-dependent response of the active medium to these deformations can lead to the reversal of spontaneously generated active flows. We explain the mechanism behind this phenomenon based on the interaction between the active flow and the viscoelastic medium. We show the importance of relaxation time scales of both the polymers and the active particles and provide a phase space over which such spontaneous flow reversals can be observed. Our results suggest new experiments investigating the role of controlled pulses of activity in living systems ensnared in complex mircoenvironments.
Morphology of Active Deformable 3D Droplets
PHYSICAL REVIEW X 11:2 (2021) ARTN 021001
Author Correction: Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers.
Nature materials (2021)
Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers
Nature Materials Nature Research (2021)