Skip to main content
Home
Department Of Physics text logo
  • Research
    • Our research
    • Our research groups
    • Our research in action
    • Research funding support
    • Summer internships for undergraduates
  • Study
    • Undergraduates
    • Postgraduates
  • Engage
    • For alumni
    • For business
    • For schools
    • For the public
Menu
Theoretical physicists working at a blackboard collaboration pod in the Beecroft building.
Credit: Jack Hobhouse

Julia Yeomans OBE FRS

Professor of Physics

Research theme

  • Biological physics

Sub department

  • Rudolf Peierls Centre for Theoretical Physics

Research groups

  • Condensed Matter Theory
Julia.Yeomans@physics.ox.ac.uk
Telephone: 01865 (2)76884 (college),01865 (2)73992
Rudolf Peierls Centre for Theoretical Physics, room 70.10
www-thphys.physics.ox.ac.uk/people/JuliaYeomans
  • About
  • Publications

Phase separation driven by active flows

Physical Review Letters American Physical Society 130:23 (2023) 238201

Authors:

Saraswat Bhattacharyya, Julia M Yeomans

Abstract:

We extend the continuum theories of active nematohydrodynamics to model a two-fluid mixture with separate velocity fields for each fluid component, coupled through a viscous drag. The model is used to study an active nematic fluid mixed with an isotropic fluid. We find microphase separation, and argue that this results from an interplay between active anchoring and active flows driven by concentration gradients. The results may be relevant to cell sorting and the formation of lipid rafts in cell membranes.
More details from the publisher
Details from ORA
More details
More details

Spontaneous rotation of active droplets in two and three dimensions

(2023)

Authors:

Mehrana R Nejad, Julia M Yeomans
More details from the publisher

Active Nematics: Mesoscale Turbulence and Self-propelled Topological Defects

Chapter in Out-of-equilibrium Soft Matter, Royal Society of Chemistry (RSC) (2023) 88-106
More details from the publisher

Correction to: ‘Collective rotational motion of freely expanding T84 epithelial cell colonies’ (2023) by Ascione et al.

Journal of The Royal Society Interface The Royal Society 20:200 (2023) 20230114

Authors:

Flora Ascione, Sergio Caserta, Speranza Esposito, Valeria Rachela Villella, Luigi Maiuri, Mehrana R Nejad, Amin Doostmohammadi, Julia M Yeomans, Stefano Guido
More details from the publisher
More details
More details

Collective rotational motion of freely expanding T84 epithelial cell colonies

Journal of the Royal Society: Interface The Royal Society 20:199 (2023)

Authors:

Flora Ascione, Sergio Caserta, Speranza Esposito, Valeria Rachela Villella, Luigi Maiuri, Mehrana R Nejad, Amin Doostmohammadi, Julia M Yeomans, Stefano Guido

Abstract:

Coordinated rotational motion is an intriguing, yet still elusive mode of collective cell migration, which is relevant in pathological and morphogenetic processes. Most of the studies on this topic have been carried out on epithelial cells plated on micropatterned substrates, where cell motion is confined in regions of well-defined shapes coated with extracellular matrix adhesive proteins. The driver of collective rotation in such conditions has not been clearly elucidated, although it has been speculated that spatial confinement can play an essential role in triggering cell rotation. Here, we study the growth of epithelial cell colonies freely expanding (i.e. with no physical constraints) on the surface of cell culture plates and focus on collective cell rotation in such conditions, a case which has received scarce attention in the literature. One of the main findings of our work is that coordinated cell rotation spontaneously occurs in cell clusters in the free growth regime, thus implying that cell confinement is not necessary to elicit collective rotation as previously suggested. The extent of collective rotation was size and shape dependent: a highly coordinated disc-like rotation was found in small cell clusters with a round shape, while collective rotation was suppressed in large irregular cell clusters generated by merging of different clusters in the course of their growth. The angular motion was persistent in the same direction, although clockwise and anticlockwise rotations were equally likely to occur among different cell clusters. Radial cell velocity was quite low as compared to the angular velocity, in agreement with the free expansion regime where cluster growth is essentially governed by cell proliferation. A clear difference in morphology was observed between cells at the periphery and the ones in the core of the clusters, the former being more elongated and spread out as compared to the latter. Overall, our results, to our knowledge, provide the first quantitative and systematic evidence that coordinated cell rotation does not require a spatial confinement and occurs spontaneously in freely expanding epithelial cell colonies, possibly as a mechanism for the system.

More details from the publisher
Details from ORA
More details
More details

Pagination

  • First page First
  • Previous page Prev
  • …
  • Page 2
  • Page 3
  • Page 4
  • Page 5
  • Current page 6
  • Page 7
  • Page 8
  • Page 9
  • Page 10
  • …
  • Next page Next
  • Last page Last

Footer Menu

  • Contact us
  • Giving to the Dept of Physics
  • Work with us
  • Media

User account menu

  • Log in

Follow us

FIND US

Clarendon Laboratory,

Parks Road,

Oxford,

OX1 3PU

CONTACT US

Tel: +44(0)1865272200

University of Oxfrod logo Department Of Physics text logo
IOP Juno Champion logo Athena Swan Silver Award logo

© University of Oxford - Department of Physics

Cookies | Privacy policy | Accessibility statement

Built by: Versantus

  • Home
  • Research
  • Study
  • Engage
  • Our people
  • News & Comment
  • Events
  • Our facilities & services
  • About us
  • Current students
  • Staff intranet