Prof Ramin Golestanian

Abstract:

The mechanism of multivalent counterion-induced bundle formation by filamentous actin (F-actin) is studied using a coarse-grained model and molecular dynamics simulations. Real diameter size, helically ordered charge distribution and twist rigidity of F-actin are taken into account in our model. The attraction between parallel F-actins induced by multivalent counterions is studied in detail and it is found that the maximum attraction occurs between their closest charged domains. The model F-actins aggregate due to the like-charge attraction and form closely packed bundles. Counterions are mostly distributed in the narrowest gaps between neighboring F-actins inside the bundles and the channels between three adjacent F-actins correspond to the low density of the counterions. Density of the counterions varies periodically with a wave length comparable to the separation between consecutive G-actin monomers along the actin polymers. Long-lived defects in the hexagonal order of F-actins in the bundles are observed; their number increases with increasing the bundle size. A combination of electrostatic interactions and twist rigidity has been found not to change the symmetry of the F-actin helical conformation from the native symmetry. Calculation of the zero-temperature energy of hexagonally ordered model F-actins with the charge of the counterions distributed as columns of charge domains representing counterion charge density waves has shown that helical symmetries commensurate with the hexagonal lattice correspond to local minima of the energy of the system. The global minimum of energy corresponds to symmetry with the columns of charge domains arranged in the narrowest gaps between the neighboring F-actins. © 2012 The Royal Society of Chemistry.

Abstract:

The lateral Casimir force is employed to propose a nanoscale mechanical device composed of one rack and N pinions. A coupling between the pinions via torsional springs is shown to coordinate their motion through a synchronization transition. The system can work against loads that are greater than the lateral Casimir force for each device. The existence of a stable synchronized state ensures that the system could operate in full coordination without the need of delicate fine tuning of all the characteristics such as the spring constants, the corrugation amplitudes, and the distances between the rack and the pinions. © 2012 American Institute of Physics.

Abstract:

The propulsion velocity of active colloids that asymmetrically catalyze a chemical reaction is probed experimentally as a function of their sizes. It is found that over the experimentally accessible range, the velocity decays as a function of size, with a rate that is compatible with an inverse size dependence. A diffusion-reaction model for the concentrations of the fuel and waste molecules that takes into account a two-step process for the asymmetric catalytic activity on the surface of the colloid is shown to predict a similar behavior for colloids at the large size limit, with a saturation for smaller sizes. © 2012 American Physical Society.

Abstract:

The propulsion velocity of active colloids that asymmetrically catalyze a chemical reaction is probed experimentally as a function of their sizes. It is found that over the experimentally accessible range, the velocity decays as a function of size, with a rate that is compatible with an inverse size dependence. A diffusion-reaction model for the concentrations of the fuel and waste molecules that takes into account a two-step process for the asymmetric catalytic activity on the surface of the colloid is shown to predict a similar behavior for colloids at the large size limit, with a saturation for smaller sizes.

Abstract:

The propulsion velocity of active colloids that asymmetrically catalyze a chemical reaction is probed experimentally as a function of their sizes. It is found that over the experimentally accessible range, the velocity decays as a function of size, with a rate that is compatible with an inverse size dependence. A diffusion-reaction model for the concentrations of the fuel and waste molecules that takes into account a two-step process for the asymmetric catalytic activity on the surface of the colloid is shown to predict a similar behavior for colloids at the large size limit, with a saturation for smaller sizes.