Prof Ramin Golestanian

Abstract:

We examine mixtures of DNA and filamentous actin (F-actin) as a model system of like-charged rigid rods and flexible chains. Confocal microscopy reveals the formation of elongated nematic F-actin domains reticulated via defect-free vertices into a network embedded in a mesh of random DNA. Synchrotron x-ray scattering results indicate that the DNA mesh squeezes the F-actin domains into a nematic state with an interactin spacing that decreases with increasing DNA concentration as d(actin) proportional, variantrho(DNA)(-1/2). Interestingly, the system changes from a counterion-controlled regime to a depletion-controlled regime with added salt, with drastic consequences for the osmotic pressure induced phase behavior.

Abstract:

The equilibrium three dimensional shape of relatively short loops of DNA is studied using an elastic model that takes into account anisotropy in bending rigidities. Using a reasonable estimate for the anisotropy, it is found that cyclized DNA with lengths that are not integer multiples of the pitch take on nontrivial shapes that involve bending out of planes and formation of kinks. The effect of sequence inhomogeneity on the shape of DNA is addressed, and shown to enhance the geometrical features. These findings could shed some light on the role of DNA conformation in protein-DNA interactions.

Abstract:

The thermophoretic motion of a charged spherical colloidal particle and its accompanying cloud of counterions and coions in a temperature gradient is studied theoretically. Using the Debye-Hückel approximation, the Soret drift velocity of a weakly charged colloid is calculated analytically. For highly charged colloids, the nonlinear system of electrokinetic equations is solved numerically, and the effects of high surface potential, dielectrophoresis, and convection are examined. Our results are in good agreement with some of the recent experiments on highly charged colloids without using adjustable parameters.

Abstract:

The simple model of a low Reynolds number swimmer made from three spheres that are connected by two arms is considered in its general form and analyzed. The swimming velocity, force-velocity response, power consumption, and efficiency of the swimmer are calculated both for general deformations and also for specific model prescriptions. The role of noise and coherence in the stroke cycle is also discussed.

Abstract:

The coupling between corrugated surfaces due to the lateral Casimir force is employed to propose a nanoscale mechanical device composed of two racks and a pinion. The noncontact nature of the interaction allows for the system to be made frustrated by choosing the two racks to move in the same direction and forcing the pinion to choose between two opposite directions. This leads to a rich and sensitive phase behavior, which makes the device potentially useful as a mechanical {\em sensor} or {\em amplifier}. The device could also be used to make a mechanical {\em clock} signal of tunable frequency.