Condensed Matter Theory

Abstract:

Morphological changes during development, tissue repair, and disease largely rely on coordinated cell movements and are controlled by the tissue environment. Epithelial cell sheets are often subjected to large scale deformation during tissue formation. The active mechanical environment in which epithelial cells operate have the ability to promote collective oscillations, but how these cellular movements are generated and relate to collective migration remains unclear. Here, combining in vitro experiments and computational modelling we describe a novel mode of collective oscillations in confined epithelial tissues where the oscillatory motion is the dominant contribution to the cellular movements. We show that epithelial cells exhibit large-scale coherent oscillations when constrained within micro-patterns of varying shapes and sizes, and that their period and amplitude are set by the smallest confinement dimension. Using molecular perturbations, we then demonstrate that force transmission at cell-cell junctions and its coupling to cell polarity are pivotal for the generation of these collective movements. We find that the resulting tissue deformations are sufficient to trigger mechanotransduction within cells, potentially affecting a wide range of cellular processes.

Abstract:

We prove that quantum information encoded in some topological excitations, including certain Majorana zero modes, is protected in closed systems for a time scale exponentially long in system parameters. This protection holds even at infinite temperature. At lower temperatures, the decay time becomes even longer, with a temperature dependence controlled by an effective gap that is parametrically larger than the actual energy gap of the system. This nonequilibrium dynamical phenomenon is a form of prethermalization and occurs because of obstructions to the equilibration of edge or defect degrees of freedom with the bulk. We analyze the ramifications for ordered and topological phases in one, two, and three dimensions, with examples including Majorana and parafermionic zero modes in interacting spin chains. Our results are based on a nonperturbative analysis valid in any dimension, and they are illustrated by numerical simulations in one dimension. We discuss the implications for experiments on quantum-dot chains tuned into a regime supporting end Majorana zero modes and on trapped ion chains.