Universal mechanistic rules for de novo design of enzymes

(2024)

Authors:

Michalis Chatzittofi, Jaime Agudo-Canalejo, Ramin Golestanian

Charge pumps, boundary modes, and the necessity of unnecessary criticality

(2024)

Authors:

Abhishodh Prakash, SA Parameswaran

Phase ordering in binary mixtures of active nematic fluids

Physical Review E American Physical Society 110:2 (2024) 24607

Authors:

Saraswat Bhattacharyya, Julia Yeomans

Abstract:

We use a continuum, two-fluid approach to study a mixture of two active nematic fluids. Even in the absence of thermodynamically driven ordering, for mixtures of different activities we observe turbulent microphase separation, where domains form and disintegrate chaotically in an active turbulent background. This is a weak effect if there is no elastic nematic alignment between the two fluid components, but is greatly enhanced in the presence of an elastic alignment or substrate friction. We interpret the results in terms of relative flows between the two species which result from active anchoring at concentration gradients. Our results may have relevance in interpreting epithelial cell sorting and the dynamics of multispecies bacterial colonies.

Molecular dynamics simulations of microscopic structural transition and macroscopic mechanical properties of magnetic gels

The Journal of Chemical Physics AIP Publishing 161:7 (2024) 074902

Authors:

Xuefeng Wei, Gaspard Junot, Ramin Golestanian, Xin Zhou, Yanting Wang, Pietro Tierno, Fanlong Meng

Nonlinear response theory of molecular machines

European Physical Society Letters IOP Publishing 147:2 (2024) 21002

Authors:

Michalis Chatzittofi, Jaime Agudo-Canalejo, Ramin Golestanian

Abstract:

Chemical affinities are responsible for driving active matter systems out of equilibrium. At the nano-scale, molecular machines interact with the surrounding environment and are subjected to external forces. The mechano-chemical coupling which arises naturally in these systems reveals a complex interplay between chemical and mechanical degrees of freedom with strong impact on their active mechanism. By considering various models far from equilibrium, we show that the tuning of applied forces gives rise to a nonlinear response that causes a non-monotonic behaviour in the machines’ activity. Our findings have implications in understanding, designing, and triggering such processes by controlled application of external fields, including the collective dynamics of larger non-equilibrium systems where the total dissipation and performance might be affected by internal and inter-particle interactions.