Cell Sorting in an Active Nematic Vertex Model

Physical Review Letters American Physical Society (APS) 133:24 (2024) 248401

Authors:

Jan Rozman, Julia M Yeomans

Abstract:

<jats:p>We study a mixture of extensile and contractile cells using a vertex model extended to include active nematic stresses. The two cell populations phase separate over time. While phase separation strengthens monotonically with an increasing magnitude of contractile activity, the dependence on extensile activity is nonmonotonic, so that sufficiently high values reduce the extent of sorting. We interpret this by showing that extensile activity renders the system motile, enabling cells to undergo neighbor exchanges. Contractile cells that come into contact as a result are then more likely to stay connected due to an effective attraction arising from contractile activity.</jats:p> <jats:sec> <jats:title/> <jats:supplementary-material> <jats:permissions> <jats:copyright-statement>Published by the American Physical Society</jats:copyright-statement> <jats:copyright-year>2024</jats:copyright-year> </jats:permissions> </jats:supplementary-material> </jats:sec>

Self organisation of invasive breast cancer driven by the interplay of active and passive nematic dynamics

(2024)

Authors:

Pablo Gottheil, Saraswat Bhattacharyya, Kolya Lettl, Philip Friedrich, Kilian Roth, Salvador Rivera-Moreno, Mario Merkel, Bahriye Aktas, Igor Sauer, Assal Daneshgar, Jonas Wieland, Hans Kubitschke, Anne-Sophie Wegscheider, Julia M Yeomans, Josef A Käs

Defect interactions in the non-reciprocal Cahn–Hilliard model

New Journal of Physics IOP Publishing 26:12 (2024) 123008

Authors:

Navdeep Rana, Ramin Golestanian

Monitored fermions with conserved U(1) charge

Physical Review Research American Physical Society (APS) 6:4 (2024) 043246

Authors:

Michele Fava, Lorenzo Piroli, Denis Bernard, Adam Nahum

Emergent polar order in nonpolar mixtures with nonreciprocal interactions.

Proceedings of the National Academy of Sciences of the United States of America 121:51 (2024) e2407705121

Authors:

Giulia Pisegna, Suropriya Saha, Ramin Golestanian

Abstract:

Phenomenological rules that govern the collective behavior of complex physical systems are powerful tools because they can make concrete predictions about their universality class based on generic considerations, such as symmetries, conservation laws, and dimensionality. While in most cases such considerations are manifestly ingrained in the constituents, novel phenomenology can emerge when composite units associated with emergent symmetries dominate the behavior of the system. We study a generic class of active matter systems with nonreciprocal interactions and demonstrate the existence of true long-range polar order in two dimensions and above, both at the linear level and by including all relevant nonlinearities in the Renormalization Group sense. We achieve this by uncovering a mapping of our scalar active mixture theory to the Toner-Tu theory of dry polar active matter by employing a suitably defined polar order parameter. We then demonstrate that the complete effective field theory-which includes all the soft modes and the relevant nonlinear terms-belongs to the (Burgers-) Kardar-Parisi-Zhang universality class. This classification allows us to prove the stability of the emergent polar long-range order in scalar nonreciprocal mixtures in two dimensions, and hence a conclusive violation of the Mermin-Wagner theorem.