Long-range correlations in the mechanics of small DNA circles under topological stress revealed by multi-scale simulation

Nucleic Acids Research Oxford University Press 44:19 (2016) 9121-9130

Authors:

Thana Sutthibutpong, Christian Matek, Craig Benham, Gabriel G Slade, Agnes Noy, Charles Laughton, Jonathan PK Doye, Ard A Louis, Sarah A Harris

Abstract:

It is well established that gene regulation can be achieved through activator and repressor proteins that bind to DNA and switch particular genes on or off, and that complex metabolic networks determine the levels of transcription of a given gene at a given time. Using three complementary computational techniques to study the sequence-dependence of DNA denaturation within DNA minicircles, we have observed that whenever the ends of the DNA are constrained, information can be transferred over long distances directly by the transmission of mechanical stress through the DNA itself, without any requirement for external signalling factors. Our models combine atomistic molecular dynamics (MD) with coarse-grained simulations and statistical mechanical calculations to span three distinct spatial resolutions and timescale regimes. While they give a consensus view of the non-locality of sequence-dependent denaturation in highly bent and supercoiled DNA loops, each also reveals a unique aspect of long-range informational transfer that occurs as a result of restraining the DNA within the closed loop of the minicircles.

Quantum quenches to the attractive one-dimensional Bose gas: exact results

SciPost Physics SciPost (2016)

Authors:

L Piroli, L, P Calabrese, P, Fabian Essler

Abstract:

We study quantum quenches to the one-dimensional Bose gas with attractive interactions in the case when the initial state is an ideal one-dimensional Bose condensate. We focus on properties of the stationary state reached at late times after the quench. This displays a finite density of multi-particle bound states, whose rapidity distribution is determined exactly by means of the quench action method. We discuss the relevance of the multi-particle bound states for the physical properties of the system, computing in particular the stationary value of the local pair correlation function g2.

Filling-enforced Kondo semimetals in two-dimensional non-symmorphic crystals

(2016)

Authors:

JH Pixley, SungBin Lee, B Brandom, SA Parameswaran

Fractionalizing glide reflections in two-dimensional Z2 topologically ordered phases

Physical Review B 94:12 (2016)

Authors:

S Lee, M Hermele, SA Parameswaran

Abstract:

© 2016 American Physical Society. We study the fractionalization of space group symmetries in two-dimensional topologically ordered phases. Specifically, we focus on Z2-fractionalized phases in two dimensions whose deconfined topological excitations transform trivially under translational symmetries but projectively under glide reflections, whose quantum numbers are hence fractionalized. We accomplish this by generalizing the dichotomy between even and odd gauge theories to incorporate additional symmetries inherent to nonsymmorphic crystals. We show that the resulting fractionalization of point group quantum numbers can be detected in numerical studies of ground state wave functions. We illustrate these ideas using a microscopic model of a system of bosons at integer unit cell filling on a lattice with space group p4g that can be mapped to a half-magnetization plateau for an S=1/2 spin system on the Shastry-Sutherland lattice.

The macroscopic pancake bounce

(2016)

Authors:

Jonas Andersen Bro, Kasper Sternberg Brogaard Jensen, Alex Nygaard Larsen, Julia M Yeomans, Tina Hecksher